The magic tree house whisks Jack and Annie to the Andes Mountains in South America. Upon arrival, they encounter local farmers and learn that a baby llama has been stolen. Jack and Annie vow to rescue the animal, leading them on a treacherous journey that requires climbing to the peak of Machu Picchu and back down again. Along the way, they must use clues from a travel guide to navigate the mountain forest and complete their mission for Morgan le Fay.